The women in the clomiphene group ovulated Although Letrozole can cause women to produce multiple eggs, the result is not as common in women with PCOS or other ovulatory disorders.
Patients with PCOS are commonly hyper-responsive to gonadotropin drugs. Letrozole can cause PCOS patients to develop and ovulate an egg while keeping them at a lower risk for hyper-stimulation, which could be caused by other fertility medications. Recent studies have shown that Letrozole can be beneficial in treating unexplained infertility.
In one study, researchers measured the effects of Clomiphene and Letrozole treatment on improving pregnancy rate, miscarriage rate, incidence rate of adverse events, and the number of dominant follicles for patients with unexplained infertility. The results of the study showed that women treated with Letrozole displayed a significantly higher rate of clinical pregnancy as compared to those treated with Clomiphene. There was no statistical difference between the groups for the other fertility outcomes.
Researchers concluded that Letrozole is at least as effective as Clomiphene for treating women with unexplained infertility. Researchers compared the efficacy of Letrozole and Clomiphene treatment on women with unexplained infertility in a randomized control trial. More than double the percentage of women treated with Letrozole achieved pregnancy In addition to the higher pregnancy rate, the group treated with Letrozole also saw a statistically significant improvement in endometrial receptivity when measured by endometrial thickness and other indicators.
Researchers concluded that Letrozole has a beneficial effect on the endometrium, which may improve implantation and pregnancy rates in women with unexplained infertility. Letrozole is synonymous with the term ovulation Induction and can be used in conjunction with several different fertility treatments. Many fertility doctors have shifted to prescribing Letrozole in conjunction with the following treatments:.
Timed intercourse is the simplest fertility treatment available. Letrozole is used during timed intercourse cycles to stimulate egg production and to induce ovulation. During a timed intercourse cycle, doctors use ultrasound and blood work monitoring or even a home ovulation predictor kit to monitor follicular development and egg growth.
By monitoring egg development and hormone levels, physicians are able to identify the window of time in which the woman is ovulating when fertilization is most likely to occur. This allows couples to engage in sexual intercourse at the time, which gives them the best chance of getting pregnant. Research has shown that Letrozole treatment may be more effective than Clomid for patients with unexplained infertility who are undergoing timed intercourse treatment.
In one study, patients treated with Letrozole showed statistically significant improvement in both endometrial thickness and follicular response when compared to the Clomid group.
The Letrozole group also had a significantly higher clinical pregnancy rate when compared to the Clomid group at Women whose infertility is caused by an ovulatory disorder are commonly prescribed Letrozole along with timed intercourse treatment.
Similar to a timed intercourse cycle, Letrozole may be prescribed alongside IUI treatment to stimulate egg growth and to help time ovulation properly with the insemination. IUI treatment aims to increase the number of sperm that reach the uterus and then the fallopian tubes to increase the chance that successful fertilization will occur.
Letrozole is used to increase the number of eggs available for fertilization and to improve ovulation. When more eggs are produced, there are more targets available for the sperm to shoot at. As previously discussed, Letrozole can improve endometrial receptivity by increasing endometrial thickness and blood flow.
In one study, researchers measured the effects of endometrial thickness on pregnancy outcomes after IUI. The results of the study showed a strong positive association between endometrial thickness and pregnancy outcome.
Gonadotropin medications may also be used with an IUI cycle, although Letrozole is a much more affordable option. Researchers have found that Letrozole treatment can help to achieve multi follicular development at a significantly lower cost than gonadotropins.
Multifollicular development is useful with IUI treatment because it can result in more eggs being ovulated. As mentioned above, more eggs mean more targets for the sperm to fertilize. Some fertility specialists or gynecologists will not prescribe Femara Others will use it — after explaining to the patient that there has been concerns raised regarding the potential for increased rates of birth defects. Share on facebook. Share on twitter. Share on linkedin.
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Once the follicles have grown to 18mm or larger, you will be given an injection of hCG to trigger ovulation and the IUI will be scheduled the following day. An ultrasound is recommended during your first treatment cycle to check the effectiveness of the medications. If you are timing the IUI by ovulation predictor kit, you should start checking your urine early in the morning with the kit on Cycle Day Most women will have a positive test around Cycle Day 13 or Once the test is positive, call the clinic to schedule the IUI.
Semen collection is scheduled in the clinic the following day and the IUI is usually performed approximately 1 — 2 hours later. If you have a positive surge on a weekend you will need to leave a message early in the morning no later than am so that we may call you back to schedule your IUI for the following day.
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